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Order antabuse (Disulfiram) |
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Description Disulfiram is available with a prescription under the brand name Antabuse. Other brand or generic formulations may also be available. Antabuse is used to treat chronic alcoholism. Antabuse interferes with the metabolism of alcohol resulting in unpleasant effects when alcohol is consumed. It makes drinking alcoholic beverages an unpleasant experience. This medication must never be used without a person's knowledge. This drug is not a cure for alcoholism and must be used in combination with supportive therapy and counseling. Drug Class Antabuse produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Alcohol is metabolized by the liver enzyme alcohol dehydrogenase into acetaldehyde. Acetaldehyde is toxic. Any concentration of it in the blood causes unpleasant physiological events: rapid increase in blood flow to the skin of the face, neck, and chest, rapid heartbeat, headache, nausea, and extreme drowsiness. During alcohol metabolism after antabuse intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to as the antabuse-alcohol reaction. The intensity of these effects is determined by the individual's metabolism and the concentration of acetaldehyde in the blood. Acetaldehyde is metabolized by another enzyme called aldehyde dehydrogenase into acetate, which is essentially harmless and eventually metabolized into carbon dioxide and water. Antabuse blocks production of the enzyme aldehyde dehydrogenase. The acetaldehyde remains in the system. The concentration of acetaldehyde in the blood increases according to the amount of alcohol consumed, as do the unpleasant effects it causes. The experience of drinking alcoholic beverages, which is normally pleasant, becomes unpleasant. Antabuse (Disulfiram) does not appear to influence the rate of alcohol elimination from the body.
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